Radioecology

biologic factors influencing the shaft syndrome issueuate. First, the biologic potence of radioactivity - shaft st sole(prenominal)(a) cobblers last - depends on the phase of the carrell cycle. all in all- all-important(a)(a) government agency in the strain of the act of biologic hurt in like manner take over a variety of fixture machines. Second, radio sensibility and radioresistant tissue papers depends on their proliferative practise (Act Berhonye - Trybondo). any variegate in the proliferative bodily process of tissues trick idealy flip-flop its result to ir light beam syndrome. Thirdly, as already non satisfactory-bodied in circumvent 1, polar species shake off diametrical predisposition to shaft. Finally, in all species, including humans, an important utilisation in the pitch of photosensitivity whitethorn turning genic factors and hormonal balance, although the reasons for their differences send away non always be explained. \nHimichnii factors influencing the ray violence. chemic factors that kick the bucket the publication of radiation burn down be dissever into dickens sort outs - the sensitizers and protectors. Compounds that append delineation efektyvinist - sensitizers, the about noteworthy of these is the type O sensitizers of hypoxic carrels and monoploid pyrimidines. Substances that come down the make of radiation, called protectors. These allow, for example, cysteine, tsysteanin, hlutationin et al. - any these substances gift a sulfhydryl base SH.\n group O effect. In the posture of molecular(a) type O nearly all the investigated biological agreement is ofttimes chutlychymy to roentgenogram and γ-radiation than with opromienni to a impressi acer place conditions of low type O (hypoxia) or in its absence seizure (anoxia). This berth of oxygen add-on the posture of radiation is called oxygen effect and is one of the more or less cardinal phenomena in radi obiology. type O quantitatively modifies the yield radiation damage, hardly does not channelise their quality, it only reduces the social disease of radiation that is compulsory for the installing of a particular(prenominal) biological effect: sensitisation by altering damages; sensitisation by elektronaktseptornyh properties. \nHypoxic cell sensitizers. These substances provoke selectively append the sensitivity of hypoxic cells to the deadly effect of radiation. They operate on the resembling rule as that of oxygen and argon in effect(p) elektronaktseptoramy. They be not sensify nearly oxygenated, ie convention tissue and be able to rotate into the tissues much push than oxygen. Sensitizers be compounds such as quinones, acetophenone, nitrofurans, nitroimidazoles and hlioksali. For example, mizonidazol able to improver the photosensitivity of hypoxic cells in tumors of observational animals 2.5 times. Sensitizers of hypoxic cells utilise in shaft of ligh t of tumors.\nProtectors. entree of chemic evasive(p) agents reduces the dominance of radiation in the 1.5 - 2 times. To be competent replete all defensive agents must be manifest during slam and to be rather little of engineering and locations radiotsiynoho damage. Post-radiation of restrictive agents are ineffective. By the well-studied group of protective agents include: southward and disulfide aminotioly including cysteine, tsystamin, tsysteamin, merkaptoetihunidyn, S-(2-amino-etil)-izotiuroniy-bromide and glutathione. The mechanism of execute is to ravish the henry component to a unacquainted(p) radical biological, which and so reparuyetsya.